How to safely reduce and stop Quetiapine 100mg for sleep with Parkinson's on Madopar and Xadago?

This is an issue you have to discuss with the doctor who prescribed quetiapine and if there is a reason to stop it.

After taking quetiapine 100 mg for only two weeks, discontinuation is generally easier than after long-term treatment, but it is preferable not to stop it abruptly. Even after short-term use, sudden withdrawal can cause rebound insomnia, anxiety, nausea or irritability.

A doctor may choose a short gradual taper, for example 100 → 50 → 25 mg before stopping, but the exact schedule should be determined by your neurologist or prescribing physician.

This is particularly important because you have Parkinson’s and take Madopar and Xadago (safinamide). Do not replace quetiapine with another sleep medication or antidepressant withou...t medical advice, as safinamide has relevant drug interactions.

If quetiapine was prescribed only for insomnia, discuss with your neurologist both a short taper and a more appropriate long-term strategy for sleep. Read more

Take Quetiapine 100mg, the half dose to sleep

Quetiapine 100mg, is indeed a low dose. Please consult your doctor. It can be easily reduced and discontinued, either by reducing the dose by 25, or by 50mg. There are various medications that can be used used for sleep, and in your case, not necessarily antidopaminergic ones, such as Quetiapine.

Good evening you should ask neurologist